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KMID : 0390220210320030265
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Journal of Clinical Otolaryngology, Head and Neck Surgery
2021 Volume.32 No. 3 p.265 ~ p.269
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A Case of Metastatic Sinonasal Mucosal Melanoma Treated with Immunotherapy
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Geum Sang-Yen
Yoo Jae-Ho
Park Hee-Jun
Shin Seung-Heon
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Abstract
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Sinonasal mucosal melanoma (SMM) is rare form of melanoma and accounts for 4%-13% of all sinonasal malig- nant tumor. SMM is characterized by aggressive growth with high locoregional recurrence and distant metastasis. Immunotherapy has been known as effective therapeutic strategies in metastatic melanoma. Immune checkpoint inhibitors; anticytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and antigrogrammed cell death 1 (PD-1), demonstrated the improved prognosis in advanced malignant melanoma. Recently, authors experienced a case of SMM patient with locoregional and distance metastasis, who was successfully treated with anti-PD-1 mono- clonal antibody. We report a case of metastatic malignant melanoma with literature review.
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KEYWORD
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Sinonasal mucosal melanoma, Immunotherapy, Metastasis
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